Sleeping beauty syndrome (KLS or Kleine-Levin Syndrome) is a neurological condition typified by recurrent phases of excess amounts of slumber & behavioural alterations. At the inception of an event patients experience drowsiness & sleep for majority of the day and wake up solely for eating or going to the loo. While wakeful, there is a transformation noted in the patient’s entire conduct, mostly seeming spaced-out or infantile. The patient even becomes confused, disoriented, lethargic & indifferent (emotion-less). Such affected people are incapable of continuing schooling or job or self-tending. Majority of them are bed bound, weary & withdrawn while wakeful.
Majority of the patient populace also cite appearing bleary & hyperacusis (noise sensitive) or photophobic. In several situations, the patient would excessively or compulsively overeat (compulsive hyperphagia disorder). Cases of unrestrained, excessive sexual drive during incidents have additionally been cited, largely in the male gender. Among women, occurrences of depression have been cited. Majority of the sleeping beauty syndrome cases are observed in teen boys.
Afflicted individuals might be asymptomatic for several weeks/ months/ years & then the disorder rearing its ugly head yet again sans much caveat. Amid events those people identified with sleeping beauty syndrome seem to be sound health without any proof of dysfunction (physically/ behaviourally).
The reason for sleeping beauty syndrome arising is unknown. Hence, kin support & edification are the superlative management presently obtainable.
In the United States, this disorder appears to present itself in the Caucasian populace with 3-folds the anticipated occurrence & observed to be 6-folds more pervasive in people having Jewish inheritance.
Presentation & Signs/ Symptoms of sleeping beauty syndrome
Symptoms are cyclic till also months of ailing that are inter-speckled with even years of being asymptomatic. People ailing might frequently develop irritability, weariness &/or indifference, disorientation & cite hallucinating. Though the condition could resolve for a number of patients later on in their lives, it isn’t widespread.
KLS sufferers primarily experience hypersomnia (excess extents of drowsiness) and are frequently given treatment originally for sleep disorders. All through a KLS event, a subject mostly would be spending eighteen hours in a day sleeping. Alteration in state mentally is one more crucial sign of this condition during the event. Arousing a subject from such slumber is tricky and would exhibit tetchiness or aggressiveness when not allowed to sleep. Often symptoms like brain fog, perplexity, loss of memory for the episode, hallucinating, delusional or experiencing a dream-similar situation.
Around seventy-five percent of KLS sufferers undergo variations in consumption behaviours during events, with most of them demonstrating voracious appetite. There have been cases wherein subjects would be eating whatever is offered to them while hardly discriminating, inclusive of overeating. Nearly fifty percent of sufferers would be experiencing some kind of hypersexual behaviourism all through the episode like promiscuousness, excessively masturbates, inapt or indecent sexual overtures & other risky unusual behaviours. Hypersexuality has greater pervasiveness among men as compared to women & is linked to a more protracted condition course.
Sleeping beauty syndrome causes
Even though scientists guess that there might be a heritable tendency some deem that the disorder might be the outcome of an autoimmune condition. There needn’t be mutual exclusivity in the duo suggestions with the outcomes being a dysfunction in a part of the brain which aids in regulating functioning like slumber, appetites & body temperatures. Latest trials even indicate that there might be an association to a Datd deficit in lower striatum.
Sleeping beauty syndrome diagnosis
Diagnosing sleeping beauty syndrome is rather tricky as there is absence of any such symptom which allows for an affirmative identification. Firstly a lengthy listing of other disorders which can ape the symptoms of KLS are to be eliminated. Likely patients are given referrals to endocrinologists earlier on for checking metabolic conditions like hypothyroid condition or diabetes. Positive diagnosis with magnetic resonance imaging helps exclude many other conditions that ape KLS signs. MS, bipolar disorder or psychiatric disorders are others conditions that are erroneously diagnosed among KLS patients.
Sleeping beauty syndrome treatment
There’s absence of definite therapy for sleeping beauty syndrome. Stimulant types like oral administration of:
These are deployed for treating drowsiness, however regrettably they don’t help in improving slack cognitive state or other aspect of changed mental condition. Due to the presence of a number of resemblances amid bipolar & KLS, the use of carbamazepine, lithium are cited to being useful in several situations for staving or lessening the events. Response to therapy has mostly been restricted and there’s the need for differentiating KLS from cyclical recurrence of drowsiness in the PMS phase in teen girls which might be managed with hormone birth control.
Sleeping beauty syndrome prognosis
Life with sleeping beauty syndrome can be tough and several sufferers experience a single or duo events of depression. Even though the key symptoms might appear above suspicion to some (profuse extent of sleep, consumption & sexual behaviours) the impact could be rather incapacitating. Sleeping beauty syndrome could make it hard in maintaining regular job & in several situations unlawful charges have been the result of uncontrollable sexual behaviourisms. Periodically binging linked to the event could cause an increase in weight & such people mostly exhibiting a more than avg. body mass index. These patients might be psycho-socially stigmatized due to their weird activities at the time of an event that those around fail to understand. Several sufferers cite mortifying events from earlier stage in their adolescent years prior to the condition was deemed a feasible identification.
In several situations, KLS would subside inexplicably as it surfaces, mostly when sufferers are in their 20’s. From the patient types who have been researched, over ninety percent would be outgrowing the condition symptoms & also people having some extent of it remnant following a decade; it is generally rather mild.