On a daily basis it is quite common for a doctor to be questioned by a patient regarding the presence of osteoporosis, arthritis or both. Undeniably, most often there is an affirmative co-existence and connection between osteoporosis and arthritis, both of which are degenerative and inflammatory in nature. Age associated osteoporosis and osteoarthritis collectively is readily elucidated. In individuals of the younger age bracket, inflammatory arthritides predispose birth, exacerbation, aggravation and exaggerated signs of untimely osteoporosis. The chances of complications then are both total and limited. Family of inflammatory cytokines of TNF alpha and RANKL have a close inter-connection in bringing about concurrent arthritis and osteoporotic alterations with resultant compromise on  [...]